研究领域|免疫学|细胞免疫反应细胞免疫反应

我们是免疫和细胞治疗、疫苗开发和免疫监测中所有肽相关项目的受监管和创新的服务和产品供应商。我们的专有技术有助于推进针对癌症、传染病和自身免疫性疾病以及过敏症的新型诊断和治疗方法。

JPT 提供最广泛的产品和服务来解决细胞免疫问题。它们包括可实现快速目标发现和新表位鉴定的肽库、用于可靠临床免疫监测的肽库，以及用于细胞和免疫治疗的临床肽。

PepMix™ 肽库我们的抗原spanning PepMixes™ 可用于多种现成的肽库（例如用于 EBV、HCMV、腺病毒、BKV、HHV6 和肿瘤相关抗原）或为您的临床应用和抗原（例如表位和新表位、重叠肽库等）。我们还提供各种标准化和对照池，例如 CEFX 池和 HCMV (pp65)。请访问 PepMix™ 肽池T 细胞检测服务我们在我们的专用 S2 中提供 T 细胞检测，例如 ELISpot、ICS/流式细胞术和多聚体染色符合 ISO 9001 规定的实验室。此外，我们可以协助您进行目标选择、序列分析/生物信息学和肽库设计。我们的服使用 ELISpot 和细胞内细胞因子染色分析进行发现。请访问 PepTrack™ 肽库SpotMix 抗原发现池 SpotMixes 代表通过我们专有的超高通量 SPOT 技术合成的重叠和汇集的肽ogy 并且可以快速且低成本地获得。 SpotMix Pools 是广泛抗原靶标发现、深度 T 细胞表位发现和生物筛选的最佳选择。 SpotMix PLUS Pools 也已用于基于新表位的免疫监测。请访问 SpotMix 抗原发现池抗原肽特异性表位肽，用于在释放干扰素的 T 细胞测定（例如 ELISPOT）中刺激 T 细胞，以实现有效的免疫监测、T 细胞表位映射或免疫疗法和疫苗的开发。请访问抗原肽加载...研究领域|免疫学免疫学

JPT 开发了多种基于肽的独特产品，可对细胞免疫和体液免疫进行系统评估。除了允许发现 T 细胞和 B 细胞表位、抗原特异性 T 细胞刺激和免疫监测的肽形式外，我们的临床级产品还支持用于开发新免疫疗法和疫苗的临床试验。

细胞免疫反应

体液免疫反应

研究领域|新表位|新表位疗法开发新表位疗法高通量基因测序、生物信息学和癌症免疫疗法的技术进步使宿主的免疫系统能够用于治疗癌症。新表位可以被免疫系统识别，以将癌症与正常细胞区分开来，成为个性化癌症免疫疗法和新表位疫苗的有力候选者。我们的临床肽和肽库可满足开发个性化疗法对高质量、快速且价格合理的肽的需求。为什么与 JPT 合作？在肽药物开发和肽化学领域拥有二十年的经验我们的算法（基于 250 万种合成肽）对您的肽进行排名用于可制造性、稳定性、溶解性、疏水性等的新表位我们高效的工作流程可实现快速周转、成本效益和长肽的成功根据 ISO 9001:2015 标准监管

临床肽和池 JPT 的临床用于开发免疫疗法和细胞疗法的肽和库是在受增强的 ISO 9001:2015 质量管理体系监管的生产环境中生产的，以满足免疫疗法（如肽疫苗）的严格产品要求。根据您的免疫治疗方案的具体情况，所得产品适用于临床应用。请访问临床肽和库PepMix™ 肽库我们的抗原跨越 PepMixes™ 可用于多种现成的肽库（例如 EBV HCMV、腺病毒、BKV、HHV6 和肿瘤相关抗原）或为您的临床应用和抗原定制（例如表位和新表位、重叠肽库等）。我们还提供多种标准化和对照池，例如 CEFX 池和 HCMV (pp65)。请访问 PepMix™ 肽池加载...研究领域|Neo-EpitopesNeo-Epitopes

与世界各地的研究人员多年的合作和讨论使我们了解了新表位疗法开发的每个不同阶段的各种要求。反过来，这种理解导致了专门的肽工具的开发，以满足您的各种需求。

我们邀请您提出意见，并欢迎有机会详细讨论您的发现项目！

新表位优先排序

新表位疗法

免疫监测

产品与服务|报价请求报价请求

要接收报价，请从下面的列表中选择产品并填写报价请求。我们的客户支持通常会在一个工作日内与您联系。

您还不知道自己需要哪种产品？查看我们不同的肽产品和服务或联系我们。定制肽定制肽合成临床肽BioTides 生物素化肽肽结合物- KLH、BSAP 肽分析服务肽池定制 PepMix™ 肽池SpotMix 抗原发现池肽阵列PepStar 肽微阵列PepSpots 纤维素肽文库上的肽Pep Track™ 肽库绝对定量肽 - SpikeTides™ TQL & PLUS 肽基质上的蛋白质相互作用筛选 (PRISMA)ProteaseSpotsPeptide ELISA

Histone Peptide H2B 106:125 K120ac (H2B.1J1KFS)

Product Code: SP-His_0053

C-terminally biotinylated synthetic Histone peptide carrying 1 modification (K120ac) derived from human Histone H2B, H2B.1J1KFS (Swiss-Prot Id(s): P57053, P06899, O60814). Amino acid sequence: Ac-LAKHAVSEGTKAVT-Lys(Ac)-YTSAK-Lys(Biotinoyl)-NH2Amount: 1 vial containing 10nmol (appr. 35µg)Purity: >70% (HPLC-MS)Delivery format: Freeze-dried in amber type glass vialsApplication(s): Western Blot, Binding experiments, ELISA, Enzyme kinetics, Pull down assays, Substrate SpecifityIndication(s)/Topic(s): Cancer, Phosphatase,Kinase, Methyltransferase, Acetyltransferase, Histones, Phosphatase, Gene regulation & expression, Epigenetics, Cell signaling, Nucleosome, AgingDelivery time: 2-5 days

JPTs Histone Code Peptides As histones are a major focus of epigenetics, JPTs computational scientists compiled a unique library of synthetic posttranslationally modified and unmodified human histone peptides that is now available as individual biotinylated peptides. The peptide library consists of more than seven hundred 20mer peptides from 29 histone families (e.g. H2A[1,19,85...], H2B[1,22,42...], H3[1,23,43...], H4[1,14,44...]). Peptides carry PTMs at reported sites (e.g. acetylation, methylation, phosphorylation, citrullination) in various combinations representing natural variants. JPTs highly skilled and committed scientific staff ensures that the most appropriate methods and techniques are selected for every synthesis project. All of JPTs catalog peptides are provided with HPLC-MS analyses to confirm the identity and demonstrate the high quality of our peptides.

Benefits of JPTs Histone Code Peptides - Whole production performed in a regulated European environment according to DIN EN ISO 9001:2015 & GCLP standards; audits welcome! - For high-throughput screening the whole Histone Code Peptide library is also available displayed on peptide microarrays - Provision of freeze dried aliquots for enhanced stability - Proven track record for many applications

Histone Peptide H2B 106:125 K120ac (H2B.1J1KFS)

Selected References for Histone Peptide Tools \"Histone H2A and H4 N-Terminal Tails are Positioned by the MEP50 WD-Repeat Protein for Efficient Methylation by the PRMT5 Arginine Methyltransferase\"Burgos et al., J. Biol. Chem. (2015) - PMID: 25713080 \"H3K23me2 is a New Heterochromatic Mark in Caenorhabditis elegans\" Vandamme et al., Nucleic Acids Res. (2015) - PMID: 26476455\"Structure of the Arginine Methyltransferase PRMT5-MEP50 Reveals a Mechanism for Substrate Specificity\"Ho et al. PLOS ONE (2013) - PMID:23451136\"Use of High-Density Histone Peptide Arrays for Parsing the Specificity of a Histone-Modifying Enzyme Complex\"Shechter et al, Application Note (2013) (full text)\"Comprehensive Peptide Microarrays for Histone Research\"Schnatbaum et al, 32th EPS (2012) (full text)

Application Notes\"Use of High-Density Histone Peptide Arrays for Parsing the Specificity of a Histone-Modifying Enzyme Complex\"Shechter et al. Application Note (2013) (full text)\"Comprehensive Characterization of Antibodies Directed towards Epigenetic Histone-Modifications\" Masch et al. Application Note (2015) (full text)

Testimonial for Histone Code Peptide Microarray \"JPTs new extremely high-density histone peptide array is a dramatic leap forward for analysis of the histone code hypothesis. The complete sequence coverage across core histones and histone variants as well as the presence of common and rare histone post-translational modifications\"alone and in combination\" makes this an unparalleled tool for studying the \"writers\" and \"readers\" of the histone code. My laboratory has used these arrays to ask the sequence and PTM dependence of a histone writer enzyme and we have discovered an activity specifying code that will keep us busy for years to come.\"David Shechter, PhD, Department of Biochemistry, Albert Einstein College of Medicine, YU (NY, USA)

Histone Peptide H2B 106:125 K120ac (H2B.1J1KFS)

Technical Data:

Histone Family	Histone H2B
Modification	Acetylation
Sequence Position	Core
Isoform	H2B.1JH2B.1KH2B.FS
Biotinylation	Biotinylated Peptide
Application	ELISA
Protein Name	Histones
Organism	Homo sapiens (Human)
Indication / Topic	AcetyltransferaseEpigeneticsKinase
Number of peptides	1

Further Information:

Amount	1 vial containing 10nmol (appr. 35µg)
Specifications	C-terminally biotinylated synthetic Histone peptide carrying 1 modification (K120ac)
Documentation	Product Datasheet
Swiss-Prot ID	P57053, P06899, O60814
Sequence	Ac-LAKHAVSEGTKAVT-Lys(Ac)-YTSAK-Lys(Biotinoyl)-NH2